Reduction-degradable PEG-b-PAA-b-PEG triblock copolymer micelles incorporated with MTX for cancer chemotherapy.
作者： Yong Sun , Yihang Huang , Shaoquan Bian , Jie Liang , Yujiang Fan
DOI: 10.1016/J.COLSURFB.2013.07.056
关键词:
摘要: Abstract Reduction-breakable core–shell type polymeric micelles from reduction-degradable amphiphilic polyethylene glycol- b –polyamide amine- –polyethylene glycol triblock copolymers (PEG- –PAA- –PEG) were prepared as new drug carriers of methotrexate (MTX) for cancer chemotherapy. The PEG- –PEG synthesized in a simple one-step process under mild condition through Michael addition. Spherical with diameters ranging 65 to 123 nm successfully fabricated the copolymers. These could effectively encapsulate anti-cancer MTX core loading content around 13%. incorporation resulted little size increase but did not influence morphology micelles. was hardly released normal without DDT reductant, fast up 100% within 24 h when structure micelle broken presence DTT, thus provided potential tool tumor targeting delivery using higher concentration reductant tissues. proliferation inhibition experiments demonstrate that MTX-encapsulated show significant cytotoxicity KB, HepG2 and 4T1 cells, especiallythe cells.
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