Breast Cancer Therapy Using Monoclonal Antibodies Against Epidermal Growth Factor Receptor and HER-2

摘要: The importance of growth factors for tumor cell is inferred from many experimental observations (1–3). A large number oncogenes code molecules that are factors, their receptors, or signal-transducing activated by the receptors (4,5). These have been shown to play causal roles in transformation and tumorigenesis (6–8). Clinical studies also indicate overexpression factor such as epidermal receptor (EGFR) HER-2 (reviewed Chapter 2), which occurs commonly human cancers, including breast often correlates with poorer prognosis (9–12). Inhibitors block activities transduction pathways downstream signaling can inhibit proliferation cultured, and, some studies, xenografted cancer lines. Thus, these inhibitors may be potential new drugs treatment (13).