Anti-receptor antibodies reverse the phenotype of cells transformed by two interacting proto-oncogene encoded receptor proteins.

摘要: The neu oncogene product, p185neu, is a tyrosine kinase receptor with structural similarity to the epidermal growth factor (EGF) receptor. We have recently described that coexpression of EGF receptors and high levels normal p185c-neu lead transformation rodent fibroblasts. Anti-EGF anti-p185neu monoclonal antibodies inhibited tumorigenic these transformants implanted into nude mice. These also suppressed focus formation cells transformed by synergistic action proteins in vitro. However, enhanced stimulated cell when added transfected just encoding cDNA. data suggest specific effectors may potentially useful applications cancer therapy for neoplasms which demonstrate increased densities. In addition novel differences actions kinases acting alone or concert other receptors.