Myelostimulatory activity of recombinant human interleukin-2 in mice.

摘要: In a series of studies designed to extend our understanding interleukin-2 (IL-2) and study the effect biologic response modifiers on bone marrow, we observed that administering recombinant human (rH) IL-2 normal mice resulted in an increase frequency colony-forming units-culture (CFU-C) marrow. addition, rH was able accelerate host recovery from cyclophosphamide (CTX)- or radiation-induced marrow depression peripheral blood leukopenia. Not only can accelerate, dose-dependent manner, return cellularity, CFU-C levels following cytoreduction by CTX irradiation, but it also significantly increases greater than levels. Furthermore, prolong survival animals receiving lethal dose irradiation CTX. Thus, multiple mechanisms are responsible for synergistic therapeutic activity associated with does not act as immunomodulatory agent presence absence suppressor T cells, accelerates cytoreductive agents, resulting decreased leukopenia perhaps resistances secondary infection. plus chemotherapy may against neoplastic disease, adding immune stimulation direct antitumor drug allowing delivery higher, more effective doses chemotherapy.