Interleukin 2 infusion induces haemopoietic growth factors and modifies marrow regeneration after chemotherapy or autologous marrow transplantation.

摘要: Summary Administration of interleukin 2 (IL2) to patients with minimal residual malignant disease following myelo-ablative chemo-radiotherapy may augment immune reconstitution and reduce the risk relapse by increasing cytotoxic effector function cytokine dependent killing directed at cells. The ability IL2 generated activated killer cells inhibit haemopoietic progenitor release gamma-interferon (γIFN) tumour necrosis factor (TNF) may, however, retard recovery, as both TNF γIFN normal myelopoiesis in vitro. To determine effect infusion on myeloid regneration vivo, we have examined recovery receiving this autologous marrow transplantation or ablative chemotherapy. We find that accelerates neutrophil granulocyte-macrophage colony stimulating (GMCSF) IL3 mRNA become detectable circulating mononuclear Induction also contribute subsequent acceleration initiation GM-CSF synthesis patient fibroblasts. These results show facilitate when administered during period regeneration chemoradiotherapy.