Recombinant human TNF induces production of granulocyte–monocyte colony-stimulating factor

摘要: Tumour necrosis factor (TNF) is synthesized by macrophages exposed to endotoxin1. It produces haemorrhagic of a variety tumours in mice and cytostatic or cytocidal against various transformed cell lines vitro, but viability normal human rodent cells unaffected2–4. The role TNF unlikely be restricted the rejection tumours. Colony-stimulating factors (CSFs) are required for survival, proliferation differentiation haematopoietic progenitor cells. growth known as granulocyte-monocyte colony-stimulating (GM-CSF) has ability stimulate eosinophil stem enhance pluripotent, megakaryocyte erythroid cells5. In addition, GM-CSF stimulates functional activities mature granulocytes macrophages, example inhibition migration, phagocytosis microbes, oxidative metabolism, antibody-dependent cytotoxic killing tumour cells5–7. We show here that markedly production messenger RNA protein lung fibroblasts vascular endothelial cells, several malignant tissues.