Mechanisms of autocrine and paracrine growth control in acute myelogenous leukemia.

摘要: Blast cells of a high proportion patients with acute myelogenous leukemia (AML) proliferate in response to exogenous hematopoetic growth factors, both vitro [9, 14, 26, 36, 48, 65] and vivo [20]. Whereas leukemic colony-forming (L-CFCs) from most share their factor dependence normal committed myeloid progenitor (CFU-GMs), some AML samples autonomously form colonies agar are therefore believed bypass requirements [17, 42, 72]. Autocrine production has been identified as one mechanism used by blasts supply various growth-promoting molecules. Moreover nontransformed accessory bone marrow have shown be inducible for factors AML-derived mediators. This paper summarizes the current knowledge autocrine paracrine mechanisms whereby may achieve selective advantages includes recent data supporting concept that cytokines act concert induce optimal growth.