Prognostic Significance of Chromosome Changes in Acute Leukemia
作者： A. A. Sandberg
DOI: 10.1007/978-3-642-71213-5_3
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摘要: The recognition that chromosome changes constitute an independent variable bearing upon the prognostic aspects of acute leukemia has now been well established [1–3]. This applies equally to nonlymphocytic (ANLL) and lymphoblastic (ALL). present paper will deal with a succinct evaluation clarification relative importance cytogenetic in leukemia. chromosomal (karyotypic, cytogenetic) abnormalities concerned can be classified as follows, order their importance: 1. Specific (primary) karyotypic change 2. Secondary changes 3. The presence or absence cytogenetically normal cells marrow 4. The double minute chromosomes (DMS) homogeneously staining regions (H SR) 5. Numerical (without morphologic abnormalities)
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