Cytogenetics of the Leukemias and Lymphomas

摘要: This chapter addresses those chromosomal (karyotypic, cytogenetic) changes and aberrations in human leukemia lymphoma that have found application the analysis diagnosis of malignant conditions, will undoubtedly serve future as a basis for further molecular diagnostic approaches neoplasia. contention is based on observation changes, particularly translocations, when they involve segments are sites proto-oncogenes, often lead to displacement such genes their activation at new sites, resulting expression, abnormal, oncogenes (Bishop, 1983; Varmus, 1984; Weinberg, 1984).