Cytogenetic studies on patients with chronic T cell leukemia/lymphoma
作者： Y Ueshima , JD Rowley , D Variakojis , J Winter , L Gordon
DOI: 10.1182/BLOOD.V63.5.1028.1028
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摘要: Cytogenetic studies were performed on three patients with chronic T cell leukemia and one patient lymphoma. One of the had leukemic cells derived from a suppressor clone, another expressed OKT3, 4, 8, other two helper clone. All an abnormal karyotype in peripheral blood or bone marrow cultured without mitogen. Modal chromosome numbers 42 44/45 each 47 2 others. The structural numerical abnormalities involved almost all chromosomes, except no. 19 X chromosome. rearrangement long arm 14, break at band 14q11;3 also 14q32. An inversion 14q occurred patients; tandem translocation involving both 14 chromosomes between 17 patient. q11 our cases resembles change reported ataxia telangiectasia. This provides added support for proposal that q11–12, accompanying 14q32, may confer proliferative advantage lymphocytes, especially those origin.
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