Atypical lymphoid leukemia in ataxia telangiectasia.

摘要: We observed two sisters with ataxia telangiectasia, one of whom developed an atypical subacute lymphocytic leukemia characterized by lymphocytes and absence palpable lymphadenopathy or hepatosplenomegaly. The lack organomegaly in this patient may have been due to the underlying which was associated lymphoid hypoplasia. Cytogenetic studies showed a marker chromosome 14 [t(14q11:14q34)] both patients. sister had other complex chromosomal aberrations addition that were stable for more than mo before patient's death from complicating infection. development T cell has not previously described telangiectasia. This case further illustrates interesting interrelationships amoung immunosuppressed states, malignancy, emerging pattern propensity abnormalities various malignancies.