T-cell-subset characterization of human T-CLL.

摘要: Circulating peripheral blood tumor cells in four cases of chronic lymphoproliferative disease were immunologically characterized. By the use T-cell-specific heteroantisera and indirect immunofluorescence, all shown to involve proliferation malignant T cells. Three demonstrated morphologic clinical features consistent with lymphocytic leukemia (CLL), one case presented as a lymphosarcoma cell leukemia. Antisera specific for normal human T-cell subsets defined each arising from TH2--subset. This subset normally constitutes approximately 80% Terminal deoxynucleotidyl transferase (TdT) was not detected any CLL cases, thus supporting notion that represents malignancy mature phenotype. The patient whose TdT-positive subsequently developed acute lymphoblastic (ALL). Moreover, la-like antigen (p23,30) on two these populations. In addition, it E-rosette-positive, since only 3 4 patients capable forming spontaneous rosettes. These findings demonstrate can provide an additional important tool dissecting heterogeneity leukemias relating them more differentiated