Clonal origin of a T cell lymphoproliferative malignancy.
作者： PA Stryckmans , L Debusscher , C Heyder-Bruckner , R Heimann , IM Mandelbaum
DOI: 10.1182/BLOOD.V52.1.69.69
关键词: Cytotoxic T cell 、 T cell 、 Dehydrogenase 、 Biology 、 Malignancy 、 Peripheral blood mononuclear cell 、 Pathology 、 Interleukin 21 、 Locus (genetics) 、 Molecular biology 、 Isozyme
摘要: A woman with a T cell lymphoproliferative malignacy and heterozhgosity at the X chromosome-linked locus for glucose-6-phosphate dehydrogenase (G-6PD) isoenzymes was studied to find clonal origin of her circulating neoplastic cells. The red blood cells, polymorphonuclear whole mononuclear cell-depleted cells contained both B G-6-PD. In contrast, tumor separated by using their capacity form rosettes sheep only isoenzyme This observation strongly suggests monoclonality this malignancy.
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