Self-renewal in culture of proliferative blast progenitor cells in acute myeloblastic leukemia.

作者: RN Buick , MD Minden , EA McCulloch

DOI: 10.1182/BLOOD.V54.1.95.95

关键词:

摘要: We have proposed that colonies of cells with blastlike morphology growing in culture are derived from a blast subpopulation high proliferative potential. To test whether or not these progenitors the capacity for self-renewal, grown peripheral blood 21 patients acute myeloblastic leukemia were replated; secondary observed 17 instances, and similar to primary size, morphology, requirements. Great patient-to-patient variation was frequency colonies, but low plating efficiency significantly correlated successful remission induction. conclude detected assay at least limited self-renewal this may, along other risk factors, contribute clinical outcome.

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