The effect of 5-azacytidine and its analogues on blast cell renewal in acute myeloblastic leukemia.
作者： T Motoji , T Hoang , D Tritchler , EA McCulloch
DOI: 10.1182/BLOOD.V65.4.894.894
关键词:
摘要: Blast cells from patients with acute myeloblastic leukemia were exposed to 5-azacytidine (5-aza) and its analogues 5-aza 2'-deoxycytidine (5-aza-dr) 6-azacytidine (6-aza). Simple negative exponential survival curves obtained for the three drugs, but sensitivity varied; 5-aza-dr was most toxic, 6-aza least intermediate. Colonies surviving drug exposure replated; found increase secondary plating efficiency, whereas inactive. The findings provide indirect evidence a role DNA methylation in regulation of blast cell self-renewal.
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