Association of statin use with a pathologic complete response to neoadjuvant chemoradiation for rectal cancer

摘要: Purpose: To assess whether 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors, or statins, might enhance the efficacy of neoadjuvant chemoradiation in rectal cancer. Methods and Materials: Between 1996 2001, 358 patients with clinically resectable, nonmetastatic cancer underwent surgery at Memorial Sloan-Kettering Cancer Center after for either locally advanced tumors low-lying that would require abdominoperineal resection. We excluded 9 radiation therapy dose Results: Thirty-three (9%) used a statin, no differences clinical stage according to digital examination ultrasound compared other 324 patients. At time surgery, 23 nonstatin (7%) were found have metastatic disease, 0% statin The unadjusted pCR rates without use 30% 17%, respectively ( p = 0.10). Variables significant univariately 0.15 level entered into multivariate model, as nonsteroidal anti-inflammatory drugs (NSAIDs), which strongly associated use. odds ratio on was 4.2 (95% confidence interval, 1.7–12.1; 0.003) adjusting NSAID use, stage, type chemotherapy. Conclusion: In analysis, is an improved rate low prevalence limits power detect difference I error threshold 0.05 this analysis. Although definitive conclusions can be drawn basis retrospective study, unusually high incidence suggests statins treatment warrants further evaluation.