Occurrence of DOPA/5‐HTP Decarboxylase in Human Seminal Plasma: Kinetic Parameters and Demonstration of a Naturally Occurring Inhibitor of the Enzyme
作者： ANDRÉE C. ROBERGE , SYLVIE BOUCHARD , JOCELYNE LAVOIE , ROLAND R. TREMBLAY , JEAN MAILHOT
DOI: 10.1002/J.1939-4640.1980.TB00027.X
关键词:
摘要: The authors found that DOPA/5-HTP decarboxylase was present in the human seminal plasma and its activity lower fertile men than infertile men. Km Vmax of enzyme were, respectively, 0.88 × 10−6 M 19.8 pmol serotonin/mg protein/min. pyrldoxal-5′-phosphate (PLPHndependent, content PLP In subjects. A soluble, heat stable, diffusible inhibitor detected plasma. This naturally occurring capable reducing cat liver. Zinc inhibited both liver, suggesting involvement zinc, close relationship with PLP, decarboxylation mechanism. These findings suggest a between synthesis biogenic amines testicular function
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