Studies on 5-hydroxytryptophan decarboxylase. II. Additional inhibition studies and suggestions on the nature of the enzymic site
作者： Arthur Yuwiler , Edward Geller , Samuel Eiduson
DOI: 10.1016/0003-9861(60)90025-4
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摘要: Abstract 1. The inhibition of 5-HTP decarboxylation by 3,4′-dihydroxy-3′-carboxychalcone, 3,4,4′-trihydroxy-3′-carboxychalcone and 1-(5-hydroxyindolyl-3)-2-(3-carboxy-4-hydroxybenzoyl)ethylene was found to be competitive at both pH 6.8 8.0. 2. K m for estimated 4.0 × 10 −5 8.0 1.7 −4 6.8. 3. Preincubation experiments appear rule out the possibility that irreversibly combines a DOPA site while reacting different site. It appears possible but unlikely binds 4. These would seem strengthen view one enzymic is involved in 5-HTP.
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sci-hub.se 参考文章(10)
Hermann F. Schott, William G. Clark, DOPA decarboxylase inhibition through the interaction of coenzyme and substrate. Journal of Biological Chemistry. ,vol. 196, pp. 449- 462 ,(1952) , 10.1016/S0021-9258(18)55750-1
M. Dixon, The determination of enzyme inhibitor constants Biochemical Journal. ,vol. 55, pp. 170- 171 ,(1953) , 10.1042/BJ0550170
Hans Lineweaver, Dean Burk, The Determination of Enzyme Dissociation Constants Journal of the American Chemical Society. ,vol. 56, pp. 658- 666 ,(1934) , 10.1021/JA01318A036
Arthur Yuwiler, Edward Geller, Samuel Eiduson, Studies on 5-hydroxytryptophan decarboxylase. I. In vitro inhibition and substrate interaction Archives of Biochemistry and Biophysics. ,vol. 80, pp. 162- 173 ,(1959) , 10.1016/0003-9861(59)90354-6
E. Westermann, H. Balzer, J. Knell, Hemmung der Serotoninbildung durch α-Methyl-Dopa Naunyn-schmiedebergs Archives of Pharmacology. ,vol. 234, pp. 194- 205 ,(1958) , 10.1007/BF00246754
Donald F. Bogdanski, Bernard B. Brodie, Alfred Pletscher, Sidney Udenfriend, Identification and assay of serotonin in brain. Journal of Pharmacology and Experimental Therapeutics. ,vol. 117, pp. 82- 88 ,(1956)
William J. Hartman, Richard I. Akawie, William G. Clark, COMPETITIVE INHIBITION OF 3, 4-DIHYDROXYPHENYLALANINE (DOPA) DECARBOXYLASE IN VITRO Journal of Biological Chemistry. ,vol. 216, pp. 507- 529 ,(1955) , 10.1016/S0021-9258(19)81409-6
E. Werle, D. Aures, Über die Reinigung und Spezifität der DOPA-Decarboxylase Hoppe-Seyler´s Zeitschrift für physiologische Chemie. ,vol. 316, pp. 45- 60 ,(1959) , 10.1515/BCHM2.1959.316.1.45
Carroll T. Clark, Herbert Weissbach, Sidney Udenfriend, 5-Hydroxytryptophan decarboxylase: preparation and properties. Journal of Biological Chemistry. ,vol. 210, pp. 139- 148 ,(1954) , 10.1016/S0021-9258(18)65440-7
James A. Buzard, Priscilla D. Nytch, The effect of norepinephrine on the 5-hydroxytryptophan decarboxylase activity of rat kidney. Journal of Biological Chemistry. ,vol. 234, pp. 884- 888 ,(1959) , 10.1016/S0021-9258(18)70195-6