The hepatic effects of hypolipidemic drugs (clofibrate, nafenopin, tibric acid, and Wy-14,643) on hepatic peroxisomes and peroxisome-associated enzymes.

摘要: Male Swiss-Webster mice were fed diets containing four hypolipidemic agents which are known to induce proliferation of hepatic peroxisomes. Treatment with all drugs (clofibrate; its structural analogue, nafenopin; and two structurally unrelated clofibrate, tibric acid Wy-14,643) produced a marked hepatomegaly in the mice. The extent increase liver weight correlated well increases total DNA collective volume hepatocyte these also similar activities peroxisome-associated enzymes. most dramatic noted short-chain (8- 26-fold) medium-chain (4- 11-fold) carnitine acyltransferase. Significant catalase (twofold threefold), alpha-glycerophosphate dehydrogenase threefold) long-chain acyltransferase fourfold). Activity latter enzyme, however, is not be associated peroxisome fractions. Concomitant administration actinomycin D or cycloheximide single oral dose clofibrate diminished occurred treatment alone. finding that major activity enzymes those metabolism acyl CoA groups supports hypothesis action peroxisomes related functions.