The rapid induction of liver glycerophosphate acyltransferase in mice by clofibrate, a hypolipidemic agent.
作者： A K Das , J W Aquilina , A K Hajra
DOI: 10.1016/S0021-9258(18)32834-5
关键词: Chemistry 、 Stimulation 、 Internal medicine 、 Protein biosynthesis 、 Cycloheximide 、 Bezafibrate 、 Microsome 、 Endocrinology 、 Gemfibrozil 、 Glycerophosphate Acyltransferase 、 Clofibrate
摘要: Abstract Administration of clofibrate to adult mice (20-25 mg clofibrate/day) increased liver glycerophosphate acyltransferase (EC 2.3.1.15) activity by 2.3-fold within 24 h. This was mainly localized in the microsomal fraction. Three other hypolipidemic drugs, i.e. Bezafibrate (Boehringer Mannheim Co.), Gemfibrozil (Warner-Lambert Co.) and Wy-14,643 (Wyeth Laboratories), when fed mice, also 2-3-fold Simultaneous administration inhibitors protein biosynthesis, such as cycloheximide or actinomycin D completely abolished stimulation clofibrate.
sci-hub.st 参考文章(28)
W Stern, M E Pullman, Acyl-CoA:sn-glycerol-3-phosphate acyltransferase and the positional distribution of fatty acids in phospholipids of cultured cells. Journal of Biological Chemistry. ,vol. 253, pp. 8047- 8055 ,(1978) , 10.1016/S0021-9258(17)34359-4
David E. Moody, Janardan K. Reddy, M. Sambasiva Rao, Mitogenic effect in mouse liver induced by a hypolipidemic drug, nafenopin Virchows Archiv B Cell Pathology. ,vol. 23, pp. 291- 296 ,(1977) , 10.1007/BF02889139
C. de Duve, B. C. Pressman, R. Gianetto, R. Wattiaux, F. Appelmans, Tissue fractionation studies. 6. Intracellular distribution patterns of enzymes in rat-liver tissue* Biochemical Journal. ,vol. 60, pp. 604- 617 ,(1955) , 10.1042/BJ0600604
A.K. Hajra, C.L. Burke, C.L. Jones, Subcellular localization of acyl coenzyme A: dihydroxyacetone phosphate acyltransferase in rat liver peroxisomes (microbodies). Journal of Biological Chemistry. ,vol. 254, pp. 10896- 10900 ,(1979) , 10.1016/S0021-9258(19)86607-3
D. E. Moody, J. K. Reddy, The hepatic effects of hypolipidemic drugs (clofibrate, nafenopin, tibric acid, and Wy-14,643) on hepatic peroxisomes and peroxisome-associated enzymes. American Journal of Pathology. ,vol. 90, pp. 435- 445 ,(1978)
C.L. Jones, A.K. Hajra, Properties of guinea pig liver peroxisomal dihydroxyacetone phosphate acyltransferase. Journal of Biological Chemistry. ,vol. 255, pp. 8289- 8295 ,(1980) , 10.1016/S0021-9258(19)70645-0
J. K. Reddy, D. L. Azarnoff, C. E. Hignite, Hypolipidaemic hepatic peroxisome proliferators form a novel class of chemical carcinogens. Nature. ,vol. 283, pp. 397- 398 ,(1980) , 10.1038/283397A0
M. G. Horning, R. M. Hebert, R. J. Roth, D. L. Davis, E. C. Horning, E. P. Fischer, G. L. Jordan, Effects of ethylp-chlorophenoxyisobutyrate on biliary secretion of bile acids, cholesterol and phosphatidyl choline Lipids. ,vol. 7, pp. 114- 120 ,(1972) , 10.1007/BF02532598
Charles W. Young, Paul F. Robinson, Bertram Sacktor, Inhibition of the synthesis of protein in intact animals by acetoxycycloheximide and a metabolic derangement concomitant with this blockade Biochemical Pharmacology. ,vol. 12, pp. 855- 865 ,(1963) , 10.1016/0006-2952(63)90116-3
Amiya K. Hajra, On extraction of acyl and alkyl dihydroxyacetone phosphate from incubation mixtures. Lipids. ,vol. 9, pp. 502- 505 ,(1974) , 10.1007/BF02532495