The RCAS-TVA System for Introduction of Oncogenes into Selected Somatic Mammary Epithelial Cells in Vivo
作者： Jay P. Reddy , Yi Li
DOI: 10.1007/S10911-009-9157-1
关键词:
摘要: We have reported the use of RCAS-TVA system to model sporadic tumorigenesis upon oncogenic activation in somatic mammary epithelial cells mouse. Here we review advantages this approach as compared conventional mouse models with transgenic oncogene expression. also detail describe method for introducing genes into engineered express avian receptor tva. This may be particularly useful modeling and subsequent distinct breast cell sub-populations, including progenitor cells.
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