A TMA De-Arraying Method for High Throughput Biomarker Discovery in Tissue Research
作者： Yinhai Wang , Kienan Savage , Claire Grills , Andrena McCavigan , Jacqueline A. James
DOI: 10.1371/JOURNAL.PONE.0026007
关键词:
摘要: Background Tissue MicroArrays (TMAs) represent a potential high-throughput platform for the analysis and discovery of tissue biomarkers. As TMA slides are produced manually subject to processing sectioning artefacts, layout cores on final slide subsequent digital scan (TMA slide) is often disturbed making it difficult associate with their original position in planned map. Additionally, individual can be greatly altered contain numerous irregularities such as missing cores, grid rotation stretching. These factors demand development robust method de-arraying TMAs which identifies each core, assigns them appropriate coordinates constructed slide.
harvard.edu
sci-hub.st 参考文章(29)
Hongbin Zha, Christine Aimé-Sempé, Takaaki Sato, John C. Reed, Proapoptotic Protein Bax Heterodimerizes with Bcl-2 and Homodimerizes with Bax via a Novel Domain (BH3) Distinct from BH1 and BH2 Journal of Biological Chemistry. ,vol. 271, pp. 7440- 7444 ,(1996) , 10.1074/JBC.271.13.7440
Klaus Kayser, Dominik Radziszowski, Piotr Bzdyl, Rainer Sommer, Gian Kayser, Towards an automated virtual slide screening: theoretical considerations and practical experiences of automated tissue-based virtual diagnosis to be implemented in the Internet. Diagnostic Pathology. ,vol. 1, pp. 10- 10 ,(2006) , 10.1186/1746-1596-1-10
Catherine A Sugar, Gareth M James, Finding the Number of Clusters in a Dataset Journal of the American Statistical Association. ,vol. 98, pp. 750- 763 ,(2003) , 10.1198/016214503000000666
Anke Neumann, Cristian Lorenz, Statistical shape model based segmentation of medical images Computerized Medical Imaging and Graphics. ,vol. 22, pp. 133- 143 ,(1998) , 10.1016/S0895-6111(98)00015-9
Gerhard G Thallinger, Kerstin Baumgartner, Martin Pirklbauer, Martina Uray, Elke Pauritsch, Gabor Mehes, Charles R Buck, Kurt Zatloukal, Zlatko Trajanoski, TAMEE: data management and analysis for tissue microarrays. BMC Bioinformatics. ,vol. 8, pp. 81- 81 ,(2007) , 10.1186/1471-2105-8-81
Theodoros Mouroutis, Stephen J Roberts, Anil A Bharath, Robust cell nuclei segmentation using statistical modelling Bioimaging. ,vol. 6, pp. 79- 91 ,(1998) , 10.1002/1361-6374(199806)6:2<79::AID-BIO3>3.0.CO;2-#
K. A. DiVito, R. L. Camp, Tissue microarrays – automated analysis and future directions Breast Cancer Online. ,vol. 8, ,(2005) , 10.1017/S1470903105003111
Karel Zuiderveld, Contrast limited adaptive histogram equalization Graphics gems. pp. 474- 485 ,(1994) , 10.1016/B978-0-12-336156-1.50061-6
Bernd Lahrmann, Niels Halama, Kathi Westphal, Claudia Ernst, Zeinab Elsawaf, Peter Sinn, Franz X. Bosch, Hartmut Dickhaus, Dirk Jäger, Peter Schirmacher, Niels Grabe, Robust gridding of TMAs after whole-slide imaging using template matching. Cytometry Part A. ,vol. 77, pp. 1169- 1176 ,(2010) , 10.1002/CYTO.A.20949
Pascal Bamford, Brian Lovell, Unsupervised cell nucleus segmentation with active contours Signal Processing. ,vol. 71, pp. 203- 213 ,(1998) , 10.1016/S0165-1684(98)00145-5