Apoptosis in brain-specific autoimmune disease.
作者： Jan Bauer , Hartmut Wekerle , Hans Lassmann
DOI: 10.1016/0952-7915(95)80057-3
关键词:
摘要: Abstract Recent neuropathological studies of experimental autoimmune encephalomyelitis have focused attention on the high number cells in lesions that show typical morphological features apoptosis. Surprisingly, it has turned out vast majority apoptotic are T lymphocytes and they actually represent antigen-specific T-cell population responsible for induction disease. Taken together, these data suggest clearance inflammation nervous system is accomplished by destruction within lesions. This may explain low level central specific memory formation, as well previously unexplained phenomena ‘epitope spreading’,
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