Prevalence and risk factors associated to pruritus in Plasmodium vivax patients using chloroquine in the Brazilian Amazon.

摘要: Chloroquine-induced pruritus has been described as a common adverse event in African patients being treated for Plasmodium falciparum malaria, and associated with treatment discontinuation this setting. In Latin America, where vivax is the most species causing malaria chloroquine still used first-line schizonticidal treating parasite infection, there are no reports on chloroquine-induced pruritus. This study aimed to estimate frequency of risk factors P. vivax-infected reference centre Brazilian Amazon. cross-sectional study, who were prescribed microscopy-confirmed infection past five days actively asked about occurrence any level potential investigated. Univariable multivariable logistic regression was performed analysis possible two sets patients: (1) all interviewed (2) restricted previous use chloroquine. Among 510 interviewed, 20.4% (95%CI: 16.9-23.9%) developed during Most episodes occurred first location hands feet. multivariate entire population, only independently allergy history (adjusted odds ratio [AOR]: 1.83; 95%CI 1.02-3.31; p=0.044) high parasitaemia (AOR: 1.96: 1.22-3.13; p=0.005). 215 chloroquine, strong predictor 11.84: 3.15-44.47; p<0.001). Two (0.4%) interrupted due severity Pruritus Host-parasite interaction may play relevant role development concurs finding association history. Patients had developing Due its frequency, side effect cannot be neglected it can have major implications patients' compliance hampering elimination efforts region.