Beclin 1 and nuclear factor-κBp65 are upregulated in hepatocellular carcinoma.
作者： KAI-FU KANG , XIAO-WEI WANG , XIAO-WU CHEN , ZI-JING KANG , XIN ZHANG
DOI: 10.3892/OL.2013.1307
关键词:
摘要: There are no sensitive and specific biomarkers that aid in the clinical diagnosis prognosis of hepatocellular carcinoma (HCC). The aim present study was to determine mRNA protein expression levels beclin 1 (BECN1) nuclear factor-κB (NF-κB)p65 patients with HCC, evaluate their value as potential diagnostic prognostic biomarkers. Immunohistochemistry situ hybridization were used detect hepatic BECN1 NF-kBp65 hepatitis B virus (HBV) or cirrhosis, compared healthy subjects. level HCC tissue significantly high cirrhotic, normal tissues. cirrhotic cancer tissues, higher than NF-κBp65 in-the positively correlated HCC. abnormal closely associated development Finally, a search GeneGo pathway database observed link between through multiple proteins. These results indicate upregulated they may serve useful for
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