Infection associated with asplenia: risks, mechanisms, and prevention.

摘要: The risk of overwhelming sepsis in asplenic patients has been recognized increasingly over the past several decades, but underlying mechanisms are not fully understood, and there is controversy true magnitude value specific interventions. Review recent series indicates that postsplenectomy more likely after splenectomy childhood than adulthood may occur at any age. In some cases, documented many years surgery. pneumococcus remains predominant organism, characteristic course rapid progression to multisystem involvement with high morbidity mortality. Predisposition pneumococcal other infections reflects role spleen mechanical filtration particulate material bloodstream, generation opsonins soluble mediators phagocytosis, anatomic juxtaposition different elements immune system. Whereas vaccine indicated patients, interventions requires further evaluation.