Antiprotozoal and Antitumor Activity of Natural Polycyclic Endoperoxides: Origin, Structures and Biological Activity.

摘要: Polycyclic endoperoxides are rare natural metabolites found and isolated in plants, fungi, marine invertebrates. The purpose of this review is a comparative analysis the pharmacological potential these products. According to PASS (Prediction Activity Spectra for Substances) estimates, they more likely exhibit antiprotozoal antitumor properties. Some them now widely used clinical medicine. All polycyclic presented article demonstrate activity can be divided into three groups. third group includes endoperoxides, which show weak with reliability up 70%, only 1.1% metabolites. second largest number 65% average confidence level 70 90%. Lastly, 33.9% strong 90 99.6%. Interestingly, artemisinin its analogs 79 99.6% against obligate intracellular parasites belong genera Plasmodium, Toxoplasma, Leishmania, Coccidia. In addition activities, proportion: 4.6% 65.6% an 90%, 29.8% 98.3%. It should also noted that some properties, other activities 97%. These include antifungal Aspergillus, Candida, Cryptococcus, as well anti-inflammatory activity. This provides insights on further utilization by medicinal chemists, pharmacologists, pharmaceutical industry.