Epidermal growth factor-dependent association of phosphatidylinositol 3-kinase with the erbB3 gene product.
作者： Hong-Hee Kim , Susan L Sierke , John G Koland , None
DOI: 10.1016/S0021-9258(17)31455-2
关键词:
摘要: The ErbB3 protein is a member of the ErbB subfamily receptor tyrosine kinases. In present study, mechanism by which phosphorylated and signal-transducing functions this were investigated. When epidermal growth factor in vitro, strongly associated with regulatory p85 subunit catalytic activity phosphatidylinositol (PI) 3-kinase. association PI 3-kinase human breast cancer cells was found to be correlated constitutive phosphorylation on residues. MDA-MB-468 not constitutively phosphorylated, stimulation led residues formation functional signal transduction complex involving These results suggest that can cross-phosphorylation couple other kinases pathway manner similar insulin substrate 1 protein.
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