Soluble CD40 Ligand Impairs the Function of Peripheral Blood Angiogenic Outgrowth Cells and Increases Neointimal Formation After Arterial Injury
作者： Mihail Hristov , Denis Gümbel , Esther Lutgens , Alma Zernecke , Christian Weber
DOI: 10.1161/CIRCULATIONAHA.109.862771
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摘要: Background— Recent work has revealed an essential involvement of soluble CD40 ligand (sCD40L) in inflammation and atherosclerosis. We investigated whether sCD40L functionally affects peripheral blood–derived angiogenic early outgrowth cells (EOCs) neointimal remodeling after arterial injury. Methods Results— Besides myeloid endothelial markers, cultured human EOCs strongly expressed mRNA protein. EOC adhesion to fibronectin, fibrinogen, intercellular molecule-1, vascular cell molecule-1 under flow conditions, as well their transmigration toward stromal cell–derived factor-1α, was dose-dependently reduced preincubation with recombinant for 24 hours. Integrin expression unaffected by sCD40L, implying that integrin adhesiveness attenuated. Surface-immobilized CD40L supported much lower than fibronectin. Treatment increased superoxide anion production decreased viability proliferation. Notably...
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