Memantine does not block antiaggressive effects of morphine in mice.
作者： M. Rodríguez-Arias , C. Maldonado , M.A. Aguilar , J. Miñarro
DOI: 10.1097/00008877-200205000-00009
关键词:
摘要: The action of the noncompetitive N-methyl-D-aspartate (NMDA) receptor blocker memantine (5, 10, 20 and 40 mg/kg) was evaluated during social encounters in mice. Although a dose-dependent increase locomotion observed, only with highest dose did it reach statistical significance. Aggressive behavior decreased mg/kg memantine, contacts being increased mg/kg. Subsequently, effect these doses on antiaggressive actions morphine (10 evaluated. None affected morphine. As administration produced an at that locomotion, is unlikely glutamatergic system mediates
sci-hub.se 参考文章(18)
M Rodrı́guez-Arias, J Miñarro, M.A Aguilar, J Pinazo, V.M Simón, Effects of risperidone and SCH 23390 on isolation-induced aggression in male mice European Neuropsychopharmacology. ,vol. 8, pp. 95- 103 ,(1998) , 10.1016/S0924-977X(97)00051-5
William J. Freed, Glutamatergic mechanisms mediating stimulant and antipsychotic drug effects Neuroscience & Biobehavioral Reviews. ,vol. 18, pp. 111- 120 ,(1994) , 10.1016/0149-7634(94)90041-8
Beth Geter-Douglass, J. M. Witkin, Behavioral effects and anticonvulsant efficacies of low-affinity, uncompetitive NMDA antagonists in mice. Psychopharmacology. ,vol. 146, pp. 280- 289 ,(1999) , 10.1007/S002130051118
and Edwin Zvartau Irina Belozertseva, Anton Bespalov, Evgeny Gmiro, Wojciech Danysz, Effects of NMDA receptor channel blockade on aggression in isolated male mice Aggressive Behavior. ,vol. 25, pp. 381- 396 ,(1999) , 10.1002/(SICI)1098-2337(1999)25:5<381::AID-AB6>3.0.CO;2-B
Sandra E. File, Survjit Cheeta, Chioma Akanezi, Diazepam and nicotine increase social interaction in gerbils : a test for anxiolytic action Brain Research. ,vol. 888, pp. 311- 313 ,(2001) , 10.1016/S0006-8993(00)03102-4
RC Pierce, GV Rebec, Intraneostriatal administration of glutamate antagonists increases behavioral activation and decreases neostriatal ascorbate via nondopaminergic mechanisms The Journal of Neuroscience. ,vol. 13, pp. 4272- 4280 ,(1993) , 10.1523/JNEUROSCI.13-10-04272.1993
N. Youssif, H. P. T. Ammon, Potentiation of the locomotor activity of memantine by aminophylline. Drug Research. ,vol. 36, pp. 1717- 1720 ,(1986)
Olga N Neznanova, Elena A Blokhina, Irina A Sukhotina, Anton Y Bespalov, Motor impairment produced by ethanol and site-selective NMDA receptor antagonists in mice: tolerance and cross-tolerance. Alcohol. ,vol. 20, pp. 31- 36 ,(2000) , 10.1016/S0741-8329(99)00053-1
Sandra E. File, Animal Models for Predicting Clinical Efficacy of Anxiolytic Drugs: Social Behaviour Neuropsychobiology. ,vol. 13, pp. 55- 62 ,(1985) , 10.1159/000118163
K.H. McAllister, Ethological analysis of the effects of MK-801 upon aggressive male mice: Similarity to chlordiazepoxide Pharmacology, Biochemistry and Behavior. ,vol. 37, pp. 101- 106 ,(1990) , 10.1016/0091-3057(90)90048-M