Continuous ultrafiltration attenuates the pulmonary injury that follows open heart surgery with cardiopulmonary bypass

摘要: Abstract Background Pulmonary injury after cardiac surgery is one of the complications cardiopulmonary bypass. We evaluated ultrafiltration technique in preventing and relieving pulmonary that can follow open heart with bypass (CPB). Methods Thirty patients congenital defects were divided into two groups. In control group conventional was used without ultrafiltration. treated group, addition to same procedure, balanced plus modified throughout function, hematocrit, serum albumin, some inflammatory mediators measured. Results Compared measurements before anesthesia static compliance at 15 minutes 6 hours post had decreased by 27.8% 34.0% versus 12.6% 15.4% airway resistance increased 38.0% 45.2% 9.5% 4.7% alveolar-arterial oxygen difference 73.4% 62.0% 52.1% 35.9% group. Hemodilution from caused hematocrit albumin decrease 35.8% 32.8% 36.1% 34.5% termination CPB. After 10 40.0% 47.6%. At CPB concentrations interleukin-6, thromboxane B2, endothelin-1 160%, 265%, 890% 103%, 208%, 838% compared those anesthesia. Conclusions The combined use effectively concentrate blood, modify increase harmful mediators, attenuate lung edema injury, mitigate impairment function.