New Approaches to the Treatment of Pancreatic Cancer

摘要: The development of novel therapeutic strategies for pancreatic adenocarcinoma (PAC) has traditionally been considered particularly challenging clinical and laboratory investigators due to its aggressive underlying biology inherent resistance currently available therapies. More recently, however, advances have made in the identification promising targets intervention, along with several key insights into complex sequence genetic alterations involved evolution PAC from premalignant precursor lesion malignant cells metastatic potential. FOLFIRINOX (5-fluorouracil/leucovorin/irinotecan/oxaliplatin) recently identified as a combination cytotoxic therapy associated significant survival benefit over single-agent gemcitabine good performance status patients advanced disease; it is hoped that similar will be seen planned trials perioperative therapy. success immune anti-cytotoxic T-lymphocyte antigen-4 antibody ipilimumab melanoma spurred interest vaccines therapies other solid tumors. Certainly, concept harnessing power system cancer treatment an attractive clinicians alike. Herein we discuss recent approaches PAC, focusing particular on developments vaccine