The discovery of novel isoflavone pan peroxisome proliferator-activated receptor agonists
作者： Azadeh Matin , Munikumar Reddy Doddareddy , Navnath Gavande , Srinivas Nammi , Paul W. Groundwater
DOI: 10.1016/J.BMC.2012.11.040
关键词:
摘要: Twenty three dual PPARα and γ molecules of natural product origin, previously reported by our group, were further investigated for pan PPAR transactivation against PPARδ. The in vitro cell toxicity profile, as well as, silico study the most active within this new class agonists are also described. 3',5' Dimethoxy-7 hydroxyisoflavone 6, Ψ-baptigenin 7, 4' fluoro-7 8, 3' methoxy-7 9 identified potent studied set compared to commercially available agonist, bezafibrate 1. These novel may thus be useful future leads PPAR-related disorders, including type II diabetes mellitus metabolic syndrome.
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