Morphological and molecular heterogeneity within nonmicrosatellite instability-high colorectal cancer.
作者： Stephen J. Meltzer , David Purdie , Lisa A. Simms , Jeremy R. Jass , Coral V. A. Wynter
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摘要: Colorectal cancer (CRC) has traditionally been classified into two groups: microsatellite stable/low-level instability (MSS/MSI-L) and high-level MSI (MSI-H) groups on the basis of multiple molecular clinicopathologic criteria. Using methylated in tumor (MINT) markers 1, 2,12, 31, we stratified 77 primary CRCs three MINT++ (>2), MINT+ (1-2), MINT- (0 methylated). The MSS/MSI-L/ group was indistinguishable from MSI-H/MINT++ with respect to methylation p16(INK4a), p14(ARF), RIZ1, morphological features. only significant difference between MSI-H non-MSI-H cancers higher frequency K-ras mutation (P < 0.004) lower hMLH1 0.001) latter. These data demonstrate that separation CRC nonoverlapping (MSI-H versus MSS/MSI-L) is a misleading oversimplification.
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Hoguen Kim, Jin Jen, Bert Vogelstein, Stanley R Hamilton, None, Clinical and pathological characteristics of sporadic colorectal carcinomas with DNA replication errors in microsatellite sequences American Journal of Pathology. ,vol. 145, pp. 148- 156 ,(1994)
Sarah Halford, Peter Sasieni, Andrew Rowan, Harpreet Wasan, Walter Bodmer, Ian Talbot, Nicholas Hawkins, Robyn Ward, Ian Tomlinson, None, Low-level microsatellite instability occurs in most colorectal cancers and is a nonrandomly distributed quantitative trait. Cancer Research. ,vol. 62, pp. 53- 57 ,(2002)
Joanne Young, Lisa A. Simms, Kelli G. Biden, Coral Wynter, Vicki Whitehall, Rozemary Karamatic, Jill George, Jack Goldblatt, Ian Walpole, Sally-Anne Robin, Michael M. Borten, Russell Stitz, Jeffrey Searle, Diane McKeone, Leigh Fraser, David R. Purdie, Kay Podger, Rachael Price, Ron Buttenshaw, Michael D. Walsh, Melissa Barker, Barbara A. Leggett, Jeremy R. Jass, Features of colorectal cancers with high-level microsatellite instability occurring in familial and sporadic settings: parallel pathways of tumorigenesis. American Journal of Pathology. ,vol. 159, pp. 2107- 2116 ,(2001) , 10.1016/S0002-9440(10)63062-3
Jeremy R. Jass, Vicki L. J. Whitehall, Barbara A. Leggett, Joanne Young, Michael D. Walsh, Methylation of O-6-methylguanine DNA methyltransferase characterizes a subset of colorectal cancer with low-level DNA microsatellite instability. Cancer Research. ,vol. 61, pp. 827- 830 ,(2001)
Gabriel Capella, Minoru Toyota, Manel Esteller, Stephen B. Baylin, Miguel Angel Peinado, James G. Herman, Silvia Tortola, Hypermethylation-associated Inactivation of p14ARF Is Independent of p16INK4a Methylation and p53 Mutational Status Cancer Research. ,vol. 60, pp. 129- 133 ,(2000)
Wade S. Samowitz, Joseph A. Holden, Karen Curtin, Sandra L. Edwards, Adrianne R. Walker, Heather A. Lin, Margaret A. Robertson, Melanie F. Nichols, Kristin M. Gruenthal, Beverly J. Lynch, Mark F. Leppert, Martha L. Slattery, Inverse Relationship between Microsatellite Instability and K-ras and p53 Gene Alterations in Colon Cancer American Journal of Pathology. ,vol. 158, pp. 1517- 1524 ,(2001) , 10.1016/S0002-9440(10)64102-8
J. R. Jass, K. G. Biden, M. C. Cummings, L. A. Simms, M. Walsh, E. Schoch, S. J. Meltzer, C. Wright, J. Searle, J. Young, B. A. Leggett, Characterisation of a subtype of colorectal cancer combining features of the suppressor and mild mutator pathways. Journal of Clinical Pathology. ,vol. 52, pp. 455- 460 ,(1999) , 10.1136/JCP.52.6.455
J. G. Herman, J. R. Graff, S. Myohanen, B. D. Nelkin, S. B. Baylin, Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands Proceedings of the National Academy of Sciences of the United States of America. ,vol. 93, pp. 9821- 9826 ,(1996) , 10.1073/PNAS.93.18.9821
Hiromu Suzuki, Fumio Itoh, Minoru Toyota, Takefumi Kikuchi, Hideki Kakiuchi, Yuji Hinoda, Kohzoh Imai, Distinct methylation pattern and microsatellite instability in sporadic gastric cancer. International Journal of Cancer. ,vol. 83, pp. 309- 313 ,(1999) , 10.1002/(SICI)1097-0215(19991029)83:3<309::AID-IJC4>3.0.CO;2-Z
E J Sawyer, A Cerar, A M Hanby, P Gorman, M Arends, I C Talbot, I P M Tomlinson, Molecular characteristics of serrated adenomas of the colorectum Gut. ,vol. 51, pp. 200- 206 ,(2002) , 10.1136/GUT.51.2.200