Long-term safety of umbilical cord mesenchymal stem cells transplantation for systemic lupus erythematosus: a 6-year follow-up study

摘要: The aim of this study is to assess the long-term safety allogeneic umbilical cord mesenchymal stem cells (UC MSCs) transplantation for patients with refractory systemic lupus erythematosus (SLE). Nine SLE patients, who were steroid and immunosuppressive drugs treatment underwent MSCs in 2009, enrolled. One million UC per kilogram body weight infused intravenously at days 0 7. possible adverse events, including immediately after infusions, as well profiles observed. Blood urine routine test, liver function, electrocardiogram, chest radiography serum levels tumor markers, alpha fetal protein (AFP), cancer embryo antigen (CEA), carbohydrate 155 (CA155) CA199, assayed before 1, 2, 4 6 years transplantation. All completed two times infusions. patient had mild dizzy warm sensation 5 min infusion, symptoms disappeared quickly. No other event, fluster, headache, nausea or vomit, was There no change peripheral white blood cell count, red count platelet number these followed up years. Liver functional analysis showed that alanine aminotransferase, glutamic-oxalacetic transaminase, total bilirubin direct remained normal range newly onset abnormality detected on electrocardiogram radiography. Moreover, we found rise AFP, CEA, CA125 Our observational demonstrated a good profile patients.