Safety and Genetic Stability of Cultured Perinatal Mesenchymal Stem Cells

摘要: Perinatal mesenchymal stem cells are considered as a promising tool to treat many diseases in clinical studies. Being different with chemical or protein drugs, perinatal were used living cells. No method is well established evaluate the safety issues of This challenge not only for patients and physicians but also manufacturers administrators. Safety could come from themselves, which include, limited to, cytokine storm, unwanted differentiation, tumorigenesis. Other concerns related processing quality control when manufacturing After vitro expansion, inevitable application, may change their biological characteristics. So it critical answer whether culture decreases value increases any risk application. Preclinical studies data, control, potential factors application will be discussed this chapter.