Effects of nursing mothers on rPer1 and rPer2 circadian expressions in the neonatal rat suprachiasmatic nuclei vary with developmental stage.
作者： Hidenobu Ohta , Sato Honma , Hiroshi Abe , Ken-ichi Honma
DOI: 10.1046/J.1460-9568.2002.02016.X
关键词:
摘要: The ability of nursing mothers to entrain the circadian pacemaker rat pups was examined by measuring Per1 (rPer1) and rPer2 expression levels in suprachiasmatic nuclei (SCN). Newborn rats from under a light-dark cycle (LD) were blinded immediately after birth reared foster either LD (LD blind pups) or reversed (DL; DL pups). At postnatal day (P)6, small but significant phase differences observed gene rhythms SCN not only between sighted pups, also two groups indicating involvement both free-running maternal influence phase-resetting pups. However, P6 P13 showed delays similar extent, which suggests that lost. From P20 (the weaning), rPer1 phase-shifted different manner, rhythm being related more closely behavioural than rPer1. This finding differential on third week life. It is concluded pup oscillation depends developmental stage.
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