Effects of short-term modest weight loss on fasting and post-prandial lipoprotein sub-fractions in type 2 diabetes mellitus patients.

摘要: OBJECTIVE We assessed the efficacy of a modest weight loss (1.5 +/- 0.3 kg) and simultaneous rapid improvement in glycemic control on fasting an post-prandial lipoprotein sub-fractions nine overweight (BMI=28 1.7 kg/m(2)) well controlled Type 2 diabetic patients (HbA(1c)=7.3 0.1%). MATERIAL AND METHODS They followed non-drastical hypocaloric balanced diet (1 561 39 kcal/day) over ten days hospital. The fat content was significantly lowered from 96 12 g/day to 62 4 (p<0.03). Plasma lipid levels were measured four hours after standard breakfast lunch twice before hospitalization. very low density obtained by cumulative flotation ultracentrifugation. RESULTS This reduced two known independent cardiovascular risk factors such as excursions (p<0.05) lipemia (p<0.05). Multiple linear regression analyses identified variable accounting for ability predict capillary triglyceride clearance Improvements which also entered parameter did not appear being able these changes (p=0.4). In addition 23% (p<0.02), decrement VLDL-2 enrichment found Finally, LDL-3 cholesterol diminished LDL-2/LDL-3 mass ratio kinetics improved CONCLUSIONS Even overweight, average type can achieve significant factors, namely independently improvements.