Optimization model for UV-riboflavin corneal cross-linking.

摘要: PURPOSE To develop a theoretical model for riboflavin ultraviolet-A cross-linking treatment that can predict the increase in stiffness of corneal tissue as function ultraviolet intensity and concentration distribution, well time. METHODS A calculating (polymerization rate) was derived using Fick's second law diffusion, Lambert-Beer's light absorption, photopolymerization rate equation. Stress-strain experiments to determine Young's modulus at 5% strain were performed on 43 sets paired porcine strips different intensities (3-7 mW/cm²) concentrations (0.0%-0.5%). The experimental results correlated with simulated polymerization relationship between data. RESULTS This allows calculation one-dimensional spatial temporal distribution. total absorbed radiant exposure, defined by intensity, time, shows linear correlation measured from which threshold value 1.7 J/cm² be determined. relative polymer per depth tissue, calculated model. CONCLUSIONS predicts distribution increased and, such, used customize treatment, according patient's thickness medical indication.