Studies on the mechanism of coumarin-induced toxicity in rat hepatocytes: Comparison with dihydrocoumarin and other coumarin metabolites
作者： Brian G. Lake , Tim J.B. Gray , John G. Evans , David F.V. Lewis , Jenny A. Beamand
DOI: 10.1016/0041-008X(89)90336-0
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摘要: … In contrast to coumarin, dihydrocoumarin—which lacks the 3,4-double bond—produced … correlation for the effects of coumarin and dihydrocoumarin in rat hepatocytes. Furthermore, the …
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sci-hub.se 参考文章(35)
B. G. Lake, Investigations into the mechanism of coumarin-induced hepatotoxicity in the rat. Archives of Toxicology. ,vol. 7, pp. 16- 29 ,(1984) , 10.1007/978-3-642-69132-4_2
SHARAT D. GANGOLLI, WILLIAM H. SHILLING, PAUL GRASSO, IAN F. GAUNT, Studies on the Metabolism and Hepatotoxicity of Coumarin in the Baboon Biochemical Society Transactions. ,vol. 2, pp. 310- 312 ,(1974) , 10.1042/BST0020310
D. W. Nebert, F. M. Goujon, J. E. Gielen, Genetic expression of aryl hydrocarbon hydroxylase induction. IV. Interaction of various compounds with different forms of cytochrome P-450 and the effect on benzo(a)pyrene metabolism in vitro. Molecular Pharmacology. ,vol. 8, pp. 667- 680 ,(1972)
A W Wood, Genetic regulation of coumarin hydroxylase activity in mice. Biochemical characterization of the enzyme from two inbred strains and their F1 hybrid. Journal of Biological Chemistry. ,vol. 254, pp. 5641- 5646 ,(1979) , 10.1016/S0021-9258(18)50462-2
D.L.J. Opdyke, Monographs on fragrance raw materials Food and Cosmetics Toxicology. ,vol. 12, pp. 385- 388 ,(1974) , 10.1016/0015-6264(74)90013-3
G. Bellomo, F. Mirabelli, D. DiMonte, P. Richelmi, H. Thor, C. Orrenius, S. Orrenius, Formation and reduction of glutathione-protein mixed disulfides during oxidative stress Biochemical Pharmacology. ,vol. 36, pp. 1313- 1320 ,(1987) , 10.1016/0006-2952(87)90087-6
A. Lewis Farr, Oliver H. Lowry, Rose J. Randall, Nira J. Rosebrough, Protein Measurement with the Folin Phenol Reagent Journal of Biological Chemistry. ,vol. 193, pp. 265- 275 ,(1951)
H. K. Murer, B. R. Zeitlin, L. W. Hazleton, T. W. Tusing, R. Thiessen, TOXICITY OF COUMARIN Journal of Pharmacology and Experimental Therapeutics. ,vol. 118, pp. 348- 358 ,(1956)
J D Adams, J R Mitchell, B H Lauterburg, Plasma glutathione and glutathione disulfide in the rat: regulation and response to oxidative stress. Journal of Pharmacology and Experimental Therapeutics. ,vol. 227, pp. 749- 754 ,(1983)
Tsuneo Omura, Ryo Sato, The Carbon Monoxide-binding Pigment of Liver Microsomes Journal of Biological Chemistry. ,vol. 239, pp. 2370- 2378 ,(1964) , 10.1016/S0021-9258(20)82244-3