REGULATION OF OVARIAN FOLLICLE ATRESIA
作者： Antti Kaipia , Aaron J. W. Hsueh
DOI: 10.1146/ANNUREV.PHYSIOL.59.1.349
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摘要: The majority of ovarian follicles undergo atresia, a hormonally controlled apoptotic process. Monitoring DNA fragmentation provides quantitative and sensitive endpoint to study the hormonal regulation atresia in follicles. During follicle development, gonadotropins, together with local growth factors (IGF-I, EGF/TGF-alpha, basic FGF) cytokine (interleukin-1 beta), as well estrogens, activate different intracellular pathways rescue from demise. In contrast, TNF-alpha, Fas ligand, presumably acting through receptors death domain, androgens are atretogenic factors. These diverse signals probably converge on selective (including genes bcl-2 ICE families) regulate apoptosis. With constant loss original stockpile, ovary unique model for studying
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