Bone‐guided regeneration: from inert biomaterials to bioactive polymer (nano)composites

摘要: Natural bone is a unique nanostructured material made of collagen fibre matrix and hydroxyapatite (HA) nanocrystals, providing mechanical support protection from the vertebrate skeleton. However, in severe cases like bone-deficiencies, needs to be “externally” repaired. Initially, different biological solutions were developed bone-guided regeneration. due limitations with existing grafts, lot researches have been devoted toward biomaterials including metals, ceramics, polymers. On basis interface reactions between implant surrounding tissues, these may classified as “nearly inert” or bioactive. Interestingly, bioactive materials exhibit specific response, leading formation natural bonding junction during Recently, special attention has paid new generation materials, i.e. (nano)structured composed bioresorbable polymer reinforced inorganic compounds. While (bio)ceramic component provides bioactivity, can readily engineered such way that their resorption rate body match tissue. This review hence reports non-biological regeneration, emphasis on polymer-based our recent results obtained osseointegration The physiology, its regeneration are also described. Copyright © 2011 John Wiley & Sons, Ltd.