Characterization of polysuccinate and hydroxyapatite‐based nanocomposites containing poly(ester‐anhydride) microspheres
作者： Monika Śmiga-Matuszowicz , Katarzyna Jaszcz , Jan Łukaszczyk , Marcin Kaczmarek , Marta Lesiak
DOI: 10.1002/PAT.3368
关键词:
摘要: Repair and regeneration of bone defects with particular shape may be enhanced by in situ forming biomaterials which can used minimal invasive surgery. This study is aimed to prepare novel biodegradable nanocomposites based on poly(3-allyloxy-1,2-propylene) succinate (PSAGE) nanosized hydroxyapatite (HA). These nanocomposite materials contain poly(ester-anhydride) (PEA) microspheres embedded a polyester matrix prepared crosslinking PSAGE oligo(1,2-propylene maleate) methacrylic monomers. Methyl methacrylate one hydrophilic oligo(ethylene glycol) methacrylates different functionality various length oligooxyethylene chains were as polymerizable diluents. Incorporation degrade faster than crosslinked matrices enables formation porous structure in situ. The obtained are liquid before curing harden several minutes moderate exothermic effect. effect the composition selected properties, such water sorption, mechanical strength, porosity hydrolytic degradation process, was investigated. Rheological behavior injectability formulations studied. Analysis energy dispersive spectroscopy confirmed presence characteristic features HA materials. morphology cured subjected evaluated scanning electron microscopy. MTS cytotoxicity assay carried out for extracts from using hFOB1.19 cells. It found that exhibit dose-dependent cytotoxic response. Copyright © 2014 John Wiley & Sons, Ltd.
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