Investigation of regulatory mechanisms in coenzyme Q metabolism.

摘要: Publisher Summary Coenzyme Q (CoQ) is not only present in all cells and membranes of the eukaryotic cells, but it also synthesized broken down cells. The lipid a structural component, its major part associated with membrane. Unlike cholesterol, CoQ itself serving as substrate for other products, metabolism strictly regulated, variations amount are limited. large portion drugs soluble water, food containing substance has to be prepared continuously avoid breakdown processes. There practical procedure perform preparation diet, which proved efficient, time saving, inexpensive, functional. high turnover, indicating an extensive lipid. half-life somewhat different various organs rat and, varies between 49 125 h. products were analyzed urine, feces, some tissues rabbit after administration CoQ7 CoQ10, number metabolites identified by chemical synthesis gas chromatography. It possible prepare increased concentration specific test interactions use mixture during reconstruction. Such experiments interest studying influence membrane structure composition on functions.