Male gonadal toxicity.

作者: Marvin L. Meistrich

DOI: 10.1002/PBC.22004

关键词:

摘要: Cancer treatment with chemotherapy or radiotherapy causes gonadal toxicity in male patients. The endpoint of most concern for future reproductive options is the induction prolonged azoospermia, which may not be reversible. immediate effects therapy and its reversibility are readily observed post-pubertal patients, but same antineoplastic regimens given to prepubertal males can induce permanent azoospermia. probability azoospermia related specific agents used their doses. damaging alkylating (particularly chlorambucil, procarbazine, cyclophosphamide, melphalan, busulfan), cisplatin radiation region testicles.

参考文章(61)
Paul Van Hummelen, Andrew J. Wyrobek, Xiu R. Lowe, Michael D. Shelby, Marvin L. Meistrich, Jack B. Bishop, Sara Frias, Sara Frias, Fredrick B. Hagemeister, NOVP chemotherapy for Hodgkin's disease transiently induces sperm aneuploidies associated with the major clinical aneuploidy syndromes involving chromosomes X, Y, 18, and 21. Cancer Research. ,vol. 63, pp. 44- 51 ,(2003)
Marvin L. Meistrich, Gunapala Shetty, Inhibition of Spermatogonial Differentiation by Testosterone Journal of Andrology. ,vol. 24, pp. 135- 148 ,(2003) , 10.1002/J.1939-4640.2003.TB02652.X
W J Schull, M Otake, J V Neel, C Satoh, Y Yoshimoto, A A Awa, H Kato, The children of parents exposed to atomic bombs: estimates of the genetic doubling dose of radiation for humans. American Journal of Human Genetics. ,vol. 46, pp. 1053- 1072 ,(1990)
H Lampe, A Horwich, A Norman, J Nicholls, D P Dearnaley, Fertility after chemotherapy for testicular germ cell cancers. Journal of Clinical Oncology. ,vol. 15, pp. 239- 245 ,(1997) , 10.1200/JCO.1997.15.1.239
M L Meistrich, G Wilson, K Mathur, L M Fuller, M A Rodriguez, P McLaughlin, J E Romaguera, F F Cabanillas, C S Ha, L I Lipshultz, F B Hagemeister, Rapid recovery of spermatogenesis after mitoxantrone, vincristine, vinblastine, and prednisone chemotherapy for Hodgkin's disease. Journal of Clinical Oncology. ,vol. 15, pp. 3488- 3495 ,(1997) , 10.1200/JCO.1997.15.12.3488
Yuri E. Dubrova, Gemma Grant, Anatoliy A. Chumak, Vasyl A. Stezhka, Angela N. Karakasian, Elevated Minisatellite Mutation Rate in the Post-Chernobyl Families from Ukraine American Journal of Human Genetics. ,vol. 71, pp. 801- 809 ,(2002) , 10.1086/342729
M Lendon, I.M Hann, M.K Palmer, S.M Shalet, P.H Morris Jones, TESTICULAR HISTOLOGY AFTER COMBINATION CHEMOTHERAPY IN CHILDHOOD FOR ACUTE LYMPHOBLASTIC LEUKÆMIA The Lancet. ,vol. 312, pp. 439- 441 ,(1978) , 10.1016/S0140-6736(78)91442-3
Marvin L Meistrich, Gunapala Shetty, Hormonal suppression for fertility preservation in males and females Reproduction. ,vol. 136, pp. 691- 701 ,(2008) , 10.1530/REP-08-0096