Interactions of cisplatin and transplatin with proteins. Comparison of binding kinetics, binding sites and reactivity of the Pt-protein adducts of cisplatin and transplatin towards biological nucleophiles.
作者： Tal Peleg-Shulman , Yousef Najajreh , Dan Gibson
DOI: 10.1016/S0162-0134(02)00362-8
关键词:
摘要: In this manuscript we report on the interactions of cis-DDP (cisplatin, cis-diamminedichloroplatinum(II)) and trans-DDP (transplatin, trans-diamminedichloroplatinum(II)) with two model proteins, ubiquitin (Ub) horse heart myoglobin (Mb), attempt to answer question whether proteins that have methionine-Pt adducts can transfer platinum biological nucleophiles particularly DNA. Our study shows cisplatin transplatin form different ubiquitin: forms one major adduct, trans-[Pt(Ub)(NH(3))(2)Cl], while four distinct adducts, [Pt(Ub)(NH(3))(2)Cl], [Pt(Ub)(NH(3))(2)(H(2)O)], [Pt(Ub)(NH(3))(2)], [Pt(Ub)(NH(3))]. When binding ubiquitin, Met1 is preferred site cisplatin, but not transplatin. Cisplatin binds faster than both myoglobin. Both stable ternary when reacted 5'-guanosine monophosphate (5'-GMP) or a tetranucleotide. No Pt moiety from nucleotides was observed. Glutathione efficiently removes preformed ubiquitin.
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