PHOSPHORYLATION OF THE MYOFIBRILLAR PROTEINS
作者： S.V. Perry , H.A. Cole , N. Frearson , A.J.G. Moir , A.C. Nairn
DOI: 10.1016/B978-0-08-023178-5.50018-5
关键词:
摘要: Publisher Summary This chapter discusses the phosphorylation of myofibrillar proteins. The importance serine 20 catalyzed by 3':5'-cyclic AMP-dependent protein kinase for physiological function heart is emphasized studies on troponin isolated from perfused subjected to various interventions. In a study described in chapter, as judged incorporation 32 p , when was with Ringer solution containing -labeled inorganic phosphate, virtually all increase phosphate that occurred intervention adrenaline due 20. normal beating rabbit heart, this residue 20–30% phosphorylated and group exchanged intracellular ATP. content I did not occur immediately force increased but some seconds later. covalent only after or other. After added 3:5-cyclic kinase, Ca 2+ concentration required produce half maximal ATPase activity has be approximately doubled.
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