Unsaturated heterocyclic inhibitors of necroptosis
作者： Junying Yuan , Gregory D. Cuny , Alexei Degterev
DOI:
关键词:
摘要: The present invention relates to isolated deuterated compounds (e.g., described by Formula (I) and pharmaceutically acceptable salts thereof. also isotopically enriched compositions that include according features pharmaceutical these their use in therapy for treating conditions which necroptosis is likely play a substantial role, or those RIP1 and/or RIP3 protein contributing factor, (structure shown)
lens.org 参考文章(6)
Gregory D. Cuny, Junying Yuan, Alexei Degterev, Prakash Jagtap, Inhibitors of cellular necrosis ,(2004)
Julie F. Liu, Alpha 1A-adrenoceptor antagonists ,(2008)
Junying Yuan, Alexei Degterev, Timothy J. Mitchison, Small molecules used to increase cell death ,(2004)
Michel Warny, Andrew C. Keates, Sarah Keates, Ignazio Castagliuolo, Jeff K. Zacks, Samer Aboudola, Amir Qamar, Charalabos Pothoulakis, J. Thomas LaMont, Ciarán P. Kelly, p38 MAP kinase activation by Clostridium difficile toxin A mediates monocyte necrosis, IL-8 production, and enteritis Journal of Clinical Investigation. ,vol. 105, pp. 1147- 1156 ,(2000) , 10.1172/JCI7545
Simon F. Campbell, Peter E. Cross, David Alker, Anti-ischaemic and antihypertensive 2-[pyrimidyloxy alhoxymethyl]-1,4-dihydropyridines ,(1985)
Kanji Takahashi, Masao Naka, Shingo Yamamoto, Piperidin-2-one derivative compounds and drugs containing these compounds as the active ingredient ,(2002)