Theoretical and Experimental Basis of Hyperthermia

摘要: When hyperthermia is applied, tumors tend to be preferentially heated relative normal tissues because heat dissipation through blood flow inefficient in compared tissues. Furthermore, the vasculature more vulnerable so that accumulation of tissue necrosis due heat-induced vascular damage greater than Another factor favor selective tumor by intratumor environment. The environment nutritionally deprived and acidic, causing intracellular pH (pHi) cells low, which enhances hyperthermic cell killing. All these advantageous physiological features for a can exploited only when temperature raised 42°–43°C or above. In general, it difficult raise human cytotoxic level, yet numerous clinical trials have unequivocally demonstrated effective used combination with radiotherapy chemotherapy. Our laboratory results strongly indicate increased upon heating at noncytotoxic temperatures, resulting improvement oxygenation drug delivery cells. Importantly, we observed increase pO2 caused mild-temperature last as long 24–48 h after heating. It must remembered overall distribution during rather heterogeneous. Vascular high temperatures well increases mild may simultaneously occur different regions same relatively temperatures. Consequently, multiple mechanisms involved response treatment.