Liver Transplantation: Does Prolonged Storage Promote Non-Anastomatic Biliary Structures?

摘要: The occurrence of biliary stricutures in allografts following liver transplantation correlates with the duration preservation time. correlation between time and strictures suggests that anoxic or reperfusion injury bile duct epithelium causes stricture formation. However, relative susceptibility cells to reoxygenation is unknown. Our aims were determine vulnerability rat compare results hepatocytes. During anoxia, epithelial significantly more resistant cell killing than Rates cellular proteolysis also 2.5-fold lower hepatocytes during anoxia. In contrast increased but improved viability rate toxic oxygen species formation by was 5-fold greater reoxygenation. addition, basal levels glutathione are These data susceptible studies support hypothesis leads transplantation.